Bovine Secondary Antibodies
Cayman Chemical ANTIBODY BKT 140 500ug
A CXCR4 antagonist (IC50 = 0.91 nM); inhibits HIV-1-induced cytopathogenicity in MT-4 cells (EC50 = 4 nM); reduces CXCL12-induced migration of SUP-T1 leukemia and MDA-MB-231 at 100 nM; induces apoptosis in NB4 leukemia and RPMI-8226 multiple myeloma cancer cells at 8 and 40 µM; reduces pulmonary metastasis in an MDA-MB-231 mouse xenograft model; reduces the incidence of arthritis in a mouse model of collagen-induced arthritis
Cayman Chemical ANTIBODY Dth 500ug
A PROTAC that drives aptamer-defined protein degradation; composed of DFHBI and thalidomide; induces degradation of mCherry in HEK293T cells at 20 µM; induces degradation of p50, as well as p50 and E2F1, in MCF-7 cells at 20 µM
Cayman Chemical ANTIBODY UrodIlatIn 500ug
A renal natriuretic peptide that regulates sodium and water reabsorption in the kidney; has pharmacological effects on renal, cardiovascular, and pulmonary parameters in animals
Cayman Chemical ANTIBODY VER-50589 500ug
An isoxazole compound that inhibits Hsp90 with an IC50 value of 21 nM; produces a mean cellular antiproliferative GI50 value of 78 nM when tested against a human cancer cell line panel
Cayman Chemical ANTIBODY U-51605 500ug
A stable analog of PGH2 that inhibits both PGI and TX synthases with more selectivity towards PGI synthase; a partial agonist at TP receptors
Cayman Chemical ANTIBODY CZC-8004 500ug
An aminopyrimidine that binds a range of tyrosine kinases, including ABL, BTK, FAK, FER, JAK1, SRC, SYK, TEC, TNK1, TYK2, and YES
Cayman Chemical ANTIBODY OTS514 500ug
An inhibitor of TOPK (IC50 = 2.6 nM); selectively inhibits growth of patient-derived AML cells over normal CD34+ cells; inhibits growth of small cell lung, kidney, and ovarian cancer cell lines (IC50s = 0.4-42.6 nM); increases survival in a peritoneal mouse dissemination model of ovarian cancer at 25 and 50 mg/kg; dose-dependently inhibits tumor growth in an A549 mouse xenograft model at 1, 2.5, and 5 mg/kg
Cayman Chemical ANTIBODY ngenol 500ug
A diterpenoid related to phorbol that activates PKC (Ki = 30 μM; ED50 = 27 μM) and promotes tumor formation
Cayman Chemical SatratoxIn H 500ug
A trichothecene mycotoxin; induces production of ROS, increases in MDA levels, and apoptosis in PC12 cells from 5-100 nM; cytotoxic to HUVECs (IC50 = 6.8 ng/ml), as well as HepG2, A549, A204, U937, and Jurkat cancer cells (IC50s = 1.2-3.4 ng/ml); induces ulceration of the small intestine in, and is lethal to mice (LD50 = 5.69 mg/kg)
Cayman Chemical ANTIBODY MEN10376 500ug
An NK2 receptor antagonist (pA2 = 8.08 in endothelium-deprived isolated rabbit pulmonary artery); selective for NK2 receptors in isolated rabbit pulmonary artery over NK2 receptors in isolated hamster trachea (pA2 = 5.64) and NK1 receptors in isolated guinea pig ileum (pA2 = 5.66), tissues that highly express these respective receptors, as well as NK3 receptors in isolated guinea pig cerebral cortex membranes (Ki = >10 μM); inhibits [β-Ala8]-NKA(4-10)-induced increases in bladder motility in anesthetized rats, as well as [β-Ala8]-NKA(4-10)-induced increases in bronchoconstriction in anesthetized guinea pig, at 1 and 3 μmol/kg
Cayman Chemical ANTIBODY 7-PPD-Q 500ug
A PPD-Q and derivative of 7-PPD; toxic to the bacterium V. fischeri (EC50 = 14.9 mg/L); has been found in PM2.5 samples collected at the roadside in China
Cayman Chemical ANTIBODY CTS-1027 500ug
An inhibitor of MMPs; selective for MMP-2, MMP-9, and MMP-13 (Kis= 0.22, 0.55, 0.52 nM, respectively) over MMP-3 and MMP-1 (Kis= 9.3 and 590 nM, respectively); reduces hepatocyte apoptosis and bile infarcts and increases survival in a mouse model of bile duct ligation-induced cholestatic liver injury at 10 mg/kg
Jackson Immuno Research Labs Alexa Fluor 594-AffiniPure Fab Fragment Bovine Anti-Goat IgG Fc Fragment Specific
Alexa Fluor 594-AffiniPure Fab Fragment Bovine Anti-Goat IgG Fc Fragment Specific
Jackson Immuno Research Labs R-Phycoerythrin-AffiniPure Fab Fragment Bovine Anti-Goat IgG Fc Fragment Specific
R-Phycoerythrin-AffiniPure Fab Fragment Bovine Anti-Goat IgG Fc Fragment Specific